Diurnal Blood Pressure and Heart Rate Variability in Hypertensive Patients with Cerebral Small Vessel Disease: A Case-Control Study

BackgroundWhether autonomic dysfunction contributes to cerebral small vessel disease (CSVD) remains unclear. This study aimed explore the relationship between CSVD and blood pressure variability (BPV) heart rate (HRV).MethodsThis case-control recruited 50 patients with non-CSVD hypertensive age- gender-matched controls. All participants completed a 24-h ambulatory electrocardiogram recording BP monitoring (ABPM). Differences in HRV BPV two groups were examined. indices assessed by ABPM included mean systolic (SBP), diastolic (DBP), coefficient of variation weighted standard deviation SBP DBP.ResultsCSVD had significant higher daytime SBP, nocturnal DBP (P < .05 for all). lower fall compared controls (median: 1.0 versus 6.2, respectively; P .001) more likely be non-dippers reverse dippers. There no differences variables groups. Five logistic models built correlations CSVD. separately entered into regression models, together hyperlipidemia, ischemic stroke history, current use anti-hypertensive agents, serum urea nitrogen. In 1−3, significantly correlated (r2 = 0.308−0.340). model 4, was negatively (odds ratio [OR] 0.871, 95% confidence interval [CI] 0.804−0.943; .001), r2 0.415 fitting model. 5, pattern dipping associated CSVD, non-dipper (OR 8.389, 95%CI 1.489−47.254; .016) dipper 27.008, 3.709−196.660; having highest risks 0.413).ConclusionsLower is Non-dipper have risk